LymphedemaV1, Main, Exploration, bibRecord, 006939

Seroconversion to filarial antigens in Australian defence force personnel in Timor-Leste.

Identifieur interne : 006939 ( Main/Exploration ); précédent : 006938; suivant : 006940

Seroconversion to filarial antigens in Australian defence force personnel in Timor-Leste.

Auteurs : Stephen P. Frances [Australie] ; Lisa M. Baade ; Joseph Kubofcik ; Thomas B. Nutman ; Wayne D. Melrose ; James S. Mccarthy ; Michael D. Nissen

Source :

The American journal of tropical medicine and hygiene [ 1476-1645 ] ; 2008.

RBID : pubmed:18385349

Descripteurs français

KwdFr :
- Animaux, Anticorps antihelminthe (immunologie), Antigènes d'helminthe (analyse), Australie (ethnologie), Dirofilaria, Filariose lymphatique (épidémiologie), Humains, Immunoglobuline G (sang), Indonésie (épidémiologie), Personnel militaire, Test ELISA.
MESH :
- analyse : Antigènes d'helminthe.
- ethnologie : Australie.
- immunologie : Anticorps antihelminthe.
- sang : Immunoglobuline G.
- épidémiologie : Filariose lymphatique, Indonésie.
- Animaux, Dirofilaria, Humains, Personnel militaire, Test ELISA.
Wicri :
- geographic : Indonésie.

English descriptors

KwdEn :
- Animals, Antibodies, Helminth (immunology), Antigens, Helminth (analysis), Australia (ethnology), Dirofilaria, Elephantiasis, Filarial (epidemiology), Enzyme-Linked Immunosorbent Assay, Humans, Immunoglobulin G (blood), Indonesia (epidemiology), Military Personnel.
MESH :
- chemical , analysis : Antigens, Helminth.
- chemical , blood : Immunoglobulin G.
- chemical , immunology : Antibodies, Helminth.
- geographic , epidemiology : Indonesia.
- geographic , ethnology : Australia.
- epidemiology : Elephantiasis, Filarial.
- Animals, Dirofilaria, Enzyme-Linked Immunosorbent Assay, Humans, Military Personnel.

Abstract

To investigate whether Australian soldiers were exposed to filarial parasites that cause lymphatic filariasis during a 6-month deployment to Timor-Leste, antifilarial antibody levels were measured in 907 soldiers using an enzyme linked immunosorbent assay (ELISA). Initial testing using Dirofilaria immitis antigen demonstrated that 49 of 907 (5.4%) soldiers developed antifilarial antibodies of the IgG1 subclass after deployment, whereas 1 of 944 (0.1%) seroconverted to the IgG4 subclass. When a sub sample of 88 D. immitis-reactive sera was subject to testing with an antifilarial antibody test using Brugia malayi antigen, 46 had elevated IgG antibodies, whereas 5 had elevated antibodies of the IgG4 subclass. A total of 24 soldiers seroconverted to B. malayi, as measured by parasite-specific IgG, whereas 1 seroconverted to IgG4. The relatively low number of seroconversions indicates a low but measurable risk of exposure to human filarial parasites among Australian soldiers deployed to Timor-Leste. However, to reduce the risk of exposure to these parasites, soldiers deploying to endemic areas should practice strict adherence to personal protective measures against mosquito bites.

PubMed: 18385349

Affiliations:

Australie

Le document en format XML

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<term>Dirofilaria</term>
<term>Elephantiasis, Filarial (epidemiology)</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
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<front><div type="abstract" xml:lang="en">To investigate whether Australian soldiers were exposed to filarial parasites that cause lymphatic filariasis during a 6-month deployment to Timor-Leste, antifilarial antibody levels were measured in 907 soldiers using an enzyme linked immunosorbent assay (ELISA). Initial testing using Dirofilaria immitis antigen demonstrated that 49 of 907 (5.4%) soldiers developed antifilarial antibodies of the IgG1 subclass after deployment, whereas 1 of 944 (0.1%) seroconverted to the IgG4 subclass. When a sub sample of 88 D. immitis-reactive sera was subject to testing with an antifilarial antibody test using Brugia malayi antigen, 46 had elevated IgG antibodies, whereas 5 had elevated antibodies of the IgG4 subclass. A total of 24 soldiers seroconverted to B. malayi, as measured by parasite-specific IgG, whereas 1 seroconverted to IgG4. The relatively low number of seroconversions indicates a low but measurable risk of exposure to human filarial parasites among Australian soldiers deployed to Timor-Leste. However, to reduce the risk of exposure to these parasites, soldiers deploying to endemic areas should practice strict adherence to personal protective measures against mosquito bites.</div>
</front>
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<tree><noCountry><name sortKey="Baade, Lisa M" sort="Baade, Lisa M" uniqKey="Baade L" first="Lisa M" last="Baade">Lisa M. Baade</name>
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<name sortKey="Mccarthy, James S" sort="Mccarthy, James S" uniqKey="Mccarthy J" first="James S" last="Mccarthy">James S. Mccarthy</name>
<name sortKey="Melrose, Wayne D" sort="Melrose, Wayne D" uniqKey="Melrose W" first="Wayne D" last="Melrose">Wayne D. Melrose</name>
<name sortKey="Nissen, Michael D" sort="Nissen, Michael D" uniqKey="Nissen M" first="Michael D" last="Nissen">Michael D. Nissen</name>
<name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B" last="Nutman">Thomas B. Nutman</name>
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<country name="Australie"><noRegion><name sortKey="Frances, Stephen P" sort="Frances, Stephen P" uniqKey="Frances S" first="Stephen P" last="Frances">Stephen P. Frances</name>
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Serveur d'exploration sur le lymphœdème

Seroconversion to filarial antigens in Australian defence force personnel in Timor-Leste.

Seroconversion to filarial antigens in Australian defence force personnel in Timor-Leste.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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